Adrenergic contractile response in human cerebral artery and prostanoid-induced contractile response in monkey cerebral artery
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چکیده
منابع مشابه
-Adrenergic Contractile Response in Rabbit Hearts
Whereas mobilization of intracellular Ca 2 1 stimulates neuronal adenylyl cyclase via Ca 2 1 /calmodulin, mobilized Ca 2 1 directly inhibits adenylyl cyclase in other tissues. To determine the physiologic role of the Ca 2 1 -dependent interaction between Na 1 /Ca 2 1 exchange and b -adrenergic signal transduction in the intact heart, digoxin (0.3 mg/kg) was administered intravenously in rabbits...
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چکیده ندارد.
15 صفحه اولSignalling pathways involved in the contractile response to 5-HT in the human pulmonary artery.
Serotonin (5-hydroxytryptamine; 5-HT) is a potent pulmonary vasoconstrictor and mitogenic agent whose plasma level is increased in pulmonary hypertensive patients. Thus, we explored the signalling pathways involved in the contractile response to 5-HT in human pulmonary arteries (HPAs). Intact and beta-escin permeabilised rings from HPAs mounted in an organ bath system were used to assess both t...
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It is well known that a-adrenoceptors have been classified into the a1-type in postsynaptic sites and the a2-type in presynaptic sites (1). Prazosin and yohimbine are selective an tagonists of a1 and a2-adrenoceptors, re spectively (2). Norepinephrine (NE) exerts a non-selective agonistic action at each type of a-adrenoceptors (3, 4). Recent reports present evidence that postsynaptic a2 as well...
متن کاملThe roles of potassium channels in contractile response to urotensin-II in mercury chloride induced endothelial dysfunction in rat aorta
Urotensin-II (U-II), the most potent vasoconstrictor that has recently been recognized as a new candidate in cardiovascular dysfunction, might exert vasoconstriction through, at least partially, potassium channels that are predominant in both endothelial and vascular smooth muscle cells (VSMCs). The present study was designed to evaluate the roles of potassium channels in vascular responses to ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1985
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)63776-5